The words 'Cairo to Cape Town' conjure up the images of African expeditions from days of old. Even today there are a multitude of challenges that the vast continent can throw at you. Desert, river, & mountain crossings are inter-twined with stunning National Parks & some of it's best adrenaline fuelled activities & playgrounds in the world. The Cape to Cairo Road, sometimes called the Great North Road in sub-Saharan Africa, was a proposed road that stretch the length of Africa, from Cape Town to Cairo, through the Cape to Cairo Red Line of British colonies. The proposal was similar to the Cape to Cairo Railway and another proposed infrastructure project through the same colonies.
There are no ferries from Europe to Egypt and overland either have to pass through Syria or Libya both of which are challenging, Syria more so to the point of being impassable the days. So you will either have to freight a vehicle to Alexandria or deal driving through Libya from Tunisia. There are still freighters from Europe to Israel , the ships travel dock in Limassol and Gemlik in Turkey but you can't board a vehicle at either port. Italy to Israel is approx 1000 euro for two people and a car. Your problem with that will cause the problems getting into Sudan. We may be able to get an Israeli passport stamp on a separate piece of paper,very transparent when importing a car.
From the time we arrived in Ethiopia we already au fait with the various standards of buses available in Africa, which range from super-expensive coaches to third-class “chicken buses,” so named because they almost always have at least half a dozen fowl among their passengers and sometimes a goat tied to the roof. This is a trip that linger in your memory long after completion. The trip does run in both directions, so some of the departure dates below may start from Cape Town rather than Cairo.